Pyridazinone derivatives as potential anti-inflammatory agents: synthesis and biological evaluation as PDE4 inhibitors-Reference-Cited by-同舟云学术

Pyridazinone derivatives as potential anti-inflammatory agents: synthesis and biological evaluation as PDE4 inhibitors

Published:2021 Issue:4 Volume:12 Page:584-592
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Allart-Simon Ingrid¹²³⁴⁵,Moniot Aurélie⁶⁷⁸⁹¹⁰,Bisi Nicolo¹²³⁴⁵,Ponce-Vargas Miguel¹²³⁴⁵^ORCID,Audonnet Sandra⁶¹¹¹²⁹¹⁰^ORCID,Laronze-Cochard Marie¹²³⁴⁵,Sapi Janos¹²³⁴⁵,Hénon Eric¹²³⁴⁵^ORCID,Velard Frédéric⁶⁷⁸⁹¹⁰,Gérard Stéphane¹²³⁴⁵^ORCID

Affiliation:

1. Université de Reims Champagne-Ardenne

2. Institut de Chimie Moléculaire de Reims (ICMR)

3. UMR CNRS 7312

4. UFR Sciences

5. Moulin de la housse and UFR Pharmacie

6. Université de Reims-Champagne-Ardenne

7. EA 4691 Biomatériaux & Inflammation en site OSseux (BIOS)

8. UFR Pharmacie and UFR Odontologie

9. F-51096 Reims

10. France

11. URCACyt

12. UFR Pharmacie

Abstract

This work describes the development of pyridazinone derivatives bearing an indole moiety as PDE4B inhibitors and their evaluation as anti-inflammatory agents.

Funder

Centre National de la Recherche Scientifique

Conseil Régional Champagne Ardenne

Ministère de l'Enseignement Supérieur et de la Recherche

European Regional Development Fund

Reims Métropole

European Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

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