Aloe-emodin derived azoles as a new structural type of potential antibacterial agents: design, synthesis, and evaluation of the action on membrane, DNA, and MRSA DNA isomerase-Reference-Cited by-全球学者库

Aloe-emodin derived azoles as a new structural type of potential antibacterial agents: design, synthesis, and evaluation of the action on membrane, DNA, and MRSA DNA isomerase

Published:2021 Issue:4 Volume:12 Page:602-608
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Liang Xin-Yuan¹²³⁴⁵,Battini Narsaiah¹²³⁴⁵,Sui Yan-Fei¹²³⁴⁵,Ansari Mohammad Fawad¹²³⁴⁵,Gan Lin-Ling⁶⁷⁸⁹¹⁰,Zhou Cheng-He¹²³⁴⁵^ORCID

Affiliation:

1. Institute of Bioorganic & Medicinal Chemistry

2. Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University)

3. Ministry of Education

4. School of Chemistry and Chemical Engineering

5. Southwest University

6. Chongqing Engineering Research Center of Pharmaceutical Sciences

7. School of Pharmacy

8. Chongqing Medical and Pharmaceutical College

9. Chongqing 401331

10. PR China

Abstract

Tetrazole aloe-emodin 4b displayed potent efficacy against MRSA, and it was found to rapidly permeate the bacterial membrane to intercalate into DNA and form supermolecule with MRSA DNA isomerase (PDB code: 2XCS).

Funder

China Postdoctoral Science Foundation

Central Universities in China

National Natural Science Foundation of China

Chongqing Postdoctoral Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D0MD00429D

Reference65 articles.