All-in-one superparamagnetic and SERS-active niosomes for dual-targeted in vitro detection of breast cancer cells

Author:

Maurer Viktor12,Zarinwall Ajmal12,Wang Zunhao3,Wundrack Stefan3,Wundrack Nicole4,Ag Seleci Didem12,Helm Vivien1,Otenko Daniil1,Frank Claudia3,Schaper Fred4,Stosch Rainer3,Garnweitner Georg12ORCID

Affiliation:

1. Institute for Particle Technology (iPAT), Technische Universität Braunschweig, Volkmaroder Str. 5, 38104 Braunschweig, Germany

2. Center of Pharmaceutical Engineering (PVZ), Technische Universität Braunschweig, Franz-Liszt-Straße 35a, 38106 Braunschweig, Germany

3. Physikalisch-Technische Bundesanstalt (PTB), Bundesallee 100, 38116 Braunschweig, Germany

4. Institute for Biology (IBIO), Universität Magdeburg, Universitätsplatz 2, 39106 Magdeburg, Germany

Abstract

Encapsulation of iron oxide and gold nanoparticles into the bilayer structure of transferrin-modified niosomes enables greatly enhanced and contamination-free SERS-signals in vitro as well as a dual-targeting functionality towards cancer cells.

Publisher

Royal Society of Chemistry (RSC)

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