Discovery of new 5-substituted-indole-2-carboxamides as dual epidermal growth factor receptor (EGFR)/cyclin dependent kinase-2 (CDK2) inhibitors with potent antiproliferative action-Reference-Cited by-同舟云学术

Discovery of new 5-substituted-indole-2-carboxamides as dual epidermal growth factor receptor (EGFR)/cyclin dependent kinase-2 (CDK2) inhibitors with potent antiproliferative action

Published:2023 Issue:4 Volume:14 Page:734-744
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Mohamed Fatma A. M.¹,Alakilli Saleha Y. M.²,El Azab Eman Fawzy¹³,Baawad Faris A. M.⁴,Shaaban Esraa Ibrahim A.⁵,Alrub Heba Abu¹,Hendawy Omnia⁶⁷,Gomaa Hesham A. M.⁶^ORCID,Bakr Adel G.⁸,Abdelrahman Mostafa H.⁹,Trembleau Laurent¹⁰^ORCID,Mohammed Anber F.¹¹,Youssif Bahaa G. M.¹¹^ORCID

Affiliation:

1. Department of Clinical Laboratory Sciences, College of Applied Medical Sciences at Al-Qurayyat, Jouf University, Al-Qurayyat 77454, Saudi Arabia

2. Department of Biological Sciences, Faculty of Sciences, King Abdulaziz University, Jeddah 23761, Saudi Arabia

3. Biochemistry Department, Faculty of Science, Alexandria University, Alexandria 21511, Egypt

4. M.B.B.S, Faculty of Medicine, King Abdulaziz University, Jeddah 23761, Saudi Arabia

5. Department of Biochemistry, Graduate; School of Medical Sciences, Nagoya City University, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan

6. Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka 72341, Aljouf, Saudi Arabia

7. Department of Clinical Pharmacology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt

8. Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt

9. Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt

10. School of Natural and Computing Sciences, University of Aberdeen, Meston Building, Aberdeen AB243UE, UK

11. Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt

Abstract

A new series of 5-substituted-3-ethylindole-2-carboxamides 5a–k and 6a–c was designed and synthesised in an attempt to develop a dual targeted antiproliferative agent.

Funder

Al Jouf University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D3MD00038A

Reference36 articles.

1. Cu(i) complexes as new antiproliferative agents against sensitive and doxorubicin resistant colorectal cancer cells: synthesis, characterization, and mechanisms of action

2. Novel 1,2,4-triazole derivatives as potential anticancer agents: Design, synthesis, molecular docking and mechanistic studies

3. New 1,3,4‐oxadiazoles linked with the 1,2,3‐triazole moiety as antiproliferative agents targeting the EGFR tyrosine kinase

4. Risks in new drug development: Approval success rates for investigational drugs

5. Key factors in the rising cost of new drug discovery and development

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synthesis, in-silico studies, and biological evaluation of some novel 3-thiazolyl-indoles as CDK2–inhibitors;Results in Chemistry;2023-12

2. Design, Synthesis, and Biological Evaluation of Indole-2-carboxamides as Potential Multi-Target Antiproliferative Agents;Pharmaceuticals;2023-07-22

3. Evaluation of Antimicrobial, Anticholinesterase Potential of Indole Derivatives and Unexpectedly Synthesized Novel Benzodiazine: Characterization, DFT and Hirshfeld Charge Analysis;Molecules;2023-06-27