Rational design of a genetically encoded NMR zinc sensor-Reference-Cited by-同舟云学术

Rational design of a genetically encoded NMR zinc sensor

Published:2023 Issue:14 Volume:14 Page:3809-3815
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Zhao Zhuangyu¹^ORCID,Zhou Mingyang¹^ORCID,Zemerov Serge D.¹,Marmorstein Ronen¹²^ORCID,Dmochowski Ivan J.¹^ORCID

Affiliation:

1. Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, 19104-6323, USA

2. Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104-6323, USA

Abstract

Elucidating the biochemical roles of the essential metal ion, Zn2+, motivates detection strategies that are sensitive, selective, quantitative, and minimally invasive in living systems.

Funder

National Institute of General Medical Sciences

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC00437F

Reference57 articles.

1. Noninvasive MRI of -cell function using a Zn2+-responsive contrast agent

2. Imaging Insulin Secretion from Mouse Pancreas by MRI Is Improved by Use of a Zinc-Responsive MRI Sensor with Lower Affinity for Zn2+ Ions

3. Zinc-sensitive MRI contrast agent detects differential release of Zn(II) ions from the healthy vs. malignant mouse prostate

4. Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production

5. The neurobiology of zinc in health and disease

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