Validated spectral manipulations for determination of an anti-neoplastic drug and its related impurities including its hazardous degradation product

Author:

Naguib Ibrahim A.12345ORCID,Abdelaleem Eglal A.678910,Hassan Eman S.678910ORCID,Emam Aml A.678910

Affiliation:

1. Department of Pharmaceutical Chemistry

2. College of Pharmacy

3. Taif University

4. Taif 21944

5. Saudi Arabia

6. Pharmaceutical Analytical Chemistry Department

7. Faculty of Pharmacy

8. Beni-Suef University

9. Beni-Suef

10. Egypt

Abstract

Zero order absorption spectra of 12 μg mL−1 of Dacarbazine (), 5-amino-imidazole-4 carboxamide (), and 2-azahypoxanthine (…) using sterile water as a blank.

Funder

Taif University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference18 articles.

1. S. C.Sweetman , Martindale, the complete drug reference , Pharmaceutical Press , London, UK , 36th edn, 2009

2. The United States Pharmacopeia , National Formulary , United States Pharmocopeia Convention, INC , USA , 34th edn 29, 2011

3. Pharmacopoeia, B , Safety data sheet of 2- Azahypoxanthine impurity standard , 2013

4. Degradation of dacarbazine in aqueous solution

5. Impact of Light Shielding on Photo-Degradation of Dacarbazine during the Preparation Process

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2. Advanced Approaches in Green Univariate Spectrophotometric Methods;Sustainable Approaches in Pharmaceutical Sciences;2023-10-25

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