CHIP-mediated hyperubiquitylation of tau promotes its self-assembly into the insoluble tau filaments-Reference-Cited by-同舟云学术

CHIP-mediated hyperubiquitylation of tau promotes its self-assembly into the insoluble tau filaments

Published:2021 Issue:15 Volume:12 Page:5599-5610
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Kim Ji Hyeon¹²³⁴^ORCID,Lee Jeeyoung¹²³⁴^ORCID,Choi Won Hoon¹²³⁴^ORCID,Park Seoyoung⁵⁶⁷³⁴^ORCID,Park Seo Hyeong¹²³⁴,Lee Jung Hoon⁵⁶⁷³⁴^ORCID,Lim Sang Min⁸⁹¹⁰¹¹⁴^ORCID,Mun Ji Young¹²¹³¹⁴⁴^ORCID,Cho Hyun-Soo¹⁵¹⁶¹⁷¹⁸⁴^ORCID,Han Dohyun¹⁹²⁰²¹³⁴^ORCID,Suh Young Ho¹²³⁴⁵^ORCID,Lee Min Jae¹²³⁴⁵^ORCID

Affiliation:

1. Department of Biomedical Sciences

2. Seoul National University Graduate School

3. Seoul 03080

4. Korea

5. Department of Biochemistry & Molecular Biology

6. Neuroscience Research Institute

7. Seoul National University College of Medicine

8. Convergence Research Center for Diagnosis

9. Treatment and Care System of Dementia

10. Korea Institute of Science and Technology

11. Seoul 02792

12. Neural Circuit Research Group

13. Korea Brain Research Institute

14. Daegu 41062

15. Department of Systems Biology

16. College of Life Science and Biotechnology

17. Yonsei University

18. Seoul 03722

19. Proteomics Core Facility

20. Biomedical Research Institute

21. Seoul National University Hospital

Abstract

Multiple-hit model for tau aggregation, where sequential events of tau phosphorylation and hyperubiquitylation function as a key driver of the fibrillization process.

Funder

National Research Foundation of Korea

Seoul National University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC00586C

Reference54 articles.

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