Sequential intervention of anti-inflammatory and osteogenesis with silk fibroin coated polyethylene terephthalate artificial ligaments for anterior cruciate ligament reconstruction

Author:

Chen Ni1,Jin Wenhe2,Gao Han2,Hong Jiachan1,Sun Luyi2,Yao Jinrong1ORCID,Chen Xin1ORCID,Chen Jun2ORCID,Chen Shiyi2,Shao Zhengzhong1ORCID

Affiliation:

1. State Key Laboratory of Molecular Engineering of Polymers, Laboratory of Advanced Materials and Department of Macromolecular Science, Fudan University, Shanghai 200433, China

2. Sports Medicine Insititute of Fudan University, Department of Sports Medicine, Huashan Hospital, Fudan University, 12 Middle Wulumuqi Road, Shanghai, 200040, China

Abstract

A multilayer drug-loaded regenerated silk fibroin coating on PET artificial ligament with differentiated drug release behavior could sequentially intervene anti-inflammatory and osteogenesis after anterior cruciate ligament reconstruction.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Fudan University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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