A bifunctional iminophosphorane squaramide catalyzed enantioselective synthesis of hydroquinazolines via intramolecular aza-Michael reaction to α,β-unsaturated esters-Reference-Cited by-同舟云学术

A bifunctional iminophosphorane squaramide catalyzed enantioselective synthesis of hydroquinazolines via intramolecular aza-Michael reaction to α,β-unsaturated esters

Published:2021 Issue:17 Volume:12 Page:6064-6072
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Su Guanglong¹²³⁴⁵^ORCID,Thomson Connor J.¹²³⁴⁵,Yamazaki Ken¹²³⁴⁵^ORCID,Rozsar Daniel¹²³⁴⁵^ORCID,Christensen Kirsten E.¹²³⁴⁵,Hamlin Trevor A.⁶⁷⁸⁹¹⁰^ORCID,Dixon Darren J.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry

2. Chemistry Research Laboratory

3. University of Oxford

4. Oxford OX1 3TA

5. UK

6. Department of Theoretical Chemistry

7. Amsterdam Institute of Molecular and Life Sciences (AIMMS)

8. Amsterdam Center for Multiscale Modeling (ACMM)

9. Vrije Universiteit Amsterdam

10. Amsterdam

Abstract

The activation of both aromatic and aliphatic ureas as N-centered nucleophiles in intramolecular Michael addition reactions to α,β-unsaturated esters was achieved under bifunctional iminophosphorane squaramide superbase catalysis.

Funder

Bayer CropScience

Honjo International Scholarship Foundation

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC00856K

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1. An insight into the therapeutic potential of quinazoline derivatives as anticancer agents