Cell-penetrating peptide together with PEG-modified mesostructured silica nanoparticles promotes mucous permeation and oral delivery of therapeutic proteins and peptides-Reference-Cited by-全球学者库

Cell-penetrating peptide together with PEG-modified mesostructured silica nanoparticles promotes mucous permeation and oral delivery of therapeutic proteins and peptides

Published:2019 Issue:7 Volume:7 Page:2934-2950
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Tan Xinyi¹²³⁴,Zhang Yan⁵⁶⁷³⁴,Wang Qian¹²³⁴⁸,Ren Tianyang¹²³⁴,Gou Jingxin¹²³⁴,Guo Wei⁹²³⁴,Yin Tian¹⁰²³⁴,He Haibing¹²³⁴,Zhang Yu¹²³⁴,Tang Xing¹²³⁴^ORCID

Affiliation:

1. Department of Pharmaceutics

2. Shenyang Pharmaceutical University

3. Shenyang

4. China

5. Department of Chemistry

6. Normal College

7. Shenyang University

8. Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine

9. Department of Pharmacology

10. School of Traditional Chinese Materia Medica

Abstract

Electrostatic particle complexes, CPP/TPP/NP, consisting of PEG-modified silica NPs with TPP and CPP, showed satisfactory stability and mucous penetration.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Liaoning Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2019/BM/C9BM00274J

Reference39 articles.

1. Engineered Multifunctional Albumin-Decorated Porous Silicon Nanoparticles for FcRn Translocation of Insulin

2. Thiolation and Cell-Penetrating Peptide Surface Functionalization of Porous Silicon Nanoparticles for Oral Delivery of Insulin