Neuroprotective effects of nitidine in Parkinson's disease models through inhibiting microglia activation: role of the Jak2–Stat3 pathway
Author:
Affiliation:
1. Department of Neurosurgery
2. Tangdu Hospital
3. Fourth Military Medical University
4. Xi'an 710038
5. China
6. Department of Ultrasound Diagnostics
7. Department of Anesthesiology
Abstract
In this work we found that nitidine could significantly suppress microglial activationviathe Jak2–Stat3 pathway and obviously improve behavioural function in Parkinson's disease (PD) animal models, which sheds light on PD treatment.
Funder
National Natural Science Foundation of China
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA11759G
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