Nature-inspired dimerization as a strategy to modulate neuropeptide pharmacology exemplified with vasopressin and oxytocin-Reference-Cited by-同舟云学术

Nature-inspired dimerization as a strategy to modulate neuropeptide pharmacology exemplified with vasopressin and oxytocin

Published:2021 Issue:11 Volume:12 Page:4057-4062
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Dekan Zoltan¹²³⁴^ORCID,Kremsmayr Thomas⁵⁶⁷⁸^ORCID,Keov Peter⁹¹⁰²³⁴^ORCID,Godin Mathilde¹²³⁴,Teakle Ngari¹²³⁴,Dürrauer Leopold⁵⁶⁷⁸,Xiang Huang¹¹¹²⁷⁸,Gharib Dalia¹¹¹²⁷⁸,Bergmayr Christian¹¹¹²⁷⁸,Hellinger Roland¹¹¹²⁷⁸^ORCID,Gay Marina¹³¹⁴¹⁵^ORCID,Vilaseca Marta¹³¹⁴¹⁵^ORCID,Kurzbach Dennis⁵⁶⁷⁸^ORCID,Albericio Fernando¹⁶¹⁷¹⁴¹⁵^ORCID,Alewood Paul F.¹²³⁴^ORCID,Gruber Christian W.⁹¹⁰²³⁴^ORCID,Muttenthaler Markus¹²³⁴⁵^ORCID

Affiliation:

1. Institute for Molecular Bioscience

2. The University of Queensland

3. Brisbane 4072

4. Australia

5. Institute of Biological Chemistry

6. University of Vienna

7. 1090 Vienna

8. Austria

9. Faculty of Medicine

10. School of Biomedical Sciences

11. Center for Physiology and Pharmacology

12. Medical University of Vienna

13. Institute for Research in Biomedicine Barcelona

14. 08028 Barcelona

15. Spain

16. Department of Organic Chemistry

17. University of Barcelona

Abstract

Structural and pharmacological study of parallel, antiparallel and N- to C-terminal cyclized homo- and heterodimers of vasopressin and oxytocin. This study spotlights dimerization as a strategy to modulate the pharmacology of neuropeptides.

Funder

Australian Research Council

Vienna Science and Technology Fund

Austrian Science Fund

H2020 European Research Council

Österreichischen Akademie der Wissenschaften

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D0SC05501H