Synthesis and medicinal chemical characterisation of antiproliferative <i>O</i>,<i>N</i>-functionalised isopulegol derivatives-Reference-Cited by-同舟云学术

Synthesis and medicinal chemical characterisation of antiproliferative O,N-functionalised isopulegol derivatives

Published:2024 Issue:26 Volume:14 Page:18508-18518
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Le Tam Minh¹²,Njangiru Isaac Kinyua³,Vincze Anna⁴,Zupkó István³,Balogh György T.⁴,Szakonyi Zsolt¹^ORCID

Affiliation:

1. Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös utca 6, H-6720 Szeged, Hungary

2. HUN-REN–SZTE Stereochemistry, Research Group, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary

3. Institute of Pharmacodynamics and Biopharmacy, University of Szeged, H-6720, Eötvös utca 6, Szeged, Hungary

4. Department of Pharmaceutical Chemistry, Semmelweis University, Hőgyes Endre u. 9, H-1092 Budapest, Hungary

Abstract

Benzylation of isopulegol furnished O-benzyl-protected isopulegol, which was transformed into aminodiols via epoxidation followed by ring opening of the corresponding epoxides and subsequent hydrogenolysis.

Funder

Nemzeti Kutatási, Fejlesztési és Innovaciós Alap

Innovációs és Technológiai Minisztérium

Szegedi Tudományegyetem

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA03467H

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3. Regio- and Stereoselective Lithiation and C-Substitution of (S)-2-(Dibenzylamino)butane-1,4-diol via Dicarbamates

4. Lewis acid promoted stereoselective carbon-carbon bond formation of 3-formyl-.DELTA.2-isoxazolines

5. 2-Amino-4-[3′-hydroxyphenyl]-4-hydroxybutanoic acid; A potent inhibitor of rat and recombinant human kynureninase