Enhancing the efficacy of cation-independent mannose 6-phosphate receptor inhibitors by intracellular delivery-Reference-Cited by-同舟云学术

Enhancing the efficacy of cation-independent mannose 6-phosphate receptor inhibitors by intracellular delivery

Published:2016 Issue:2 Volume:52 Page:327-330
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Agarwal Vipul¹²³⁴,Toshniwal Priyanka¹²³⁴,Smith Natalie E.⁵⁶⁷⁴,Smith Nicole M.¹²³⁴,Li Binbin⁸⁹¹⁰¹¹,Clemons Tristan D.¹²³⁴,Byrne Lindsay T.¹²¹³²⁴,Kakulas Foteini¹²³⁴,Wood Fiona M.¹⁴¹⁵²³⁴,Fear Mark¹⁴¹⁵²³⁴,Corry Ben⁵⁶⁷⁴,Swaminathan Iyer K.¹²³⁴

Affiliation:

1. School of Chemistry and Biochemistry

2. The University of Western Australia

3. Crawley

4. Australia

5. Research School of Biology

6. Australian National University

7. Canberra

8. State Key Laboratory of Advanced Technology for Materials Synthesis and Processing

9. Wuhan University of Technology

10. Wuhan

11. P. R. China

12. Centre for Microscopy

13. Characterization & Analysis

14. Burn Injury Research Unit

15. School of Surgery

Abstract

Intracellular delivery of M6P/IGFII receptor inhibitors exhibits better efficacy than extracellular inhibitors to regulate TGFβ₁ mediated upregulation of profibrotic marker, collagen I.

Funder

Australian Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2016/CC/C5CC06826F

Reference36 articles.

1. Proteomics Analysis of Serum from Mutant Mice Reveals Lysosomal Proteins Selectively Transported by Each of the Two Mannose 6-Phosphate Receptors

2. Mannose 6-phosphate receptors: new twists in the tale

3. Intracellular movement of two mannose 6-phosphate receptors: return to the Golgi apparatus.

4. Mannose 6-Phosphate Receptor Targeting and its Applications in Human Diseases

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