Role of mutations in a chemoenzymatic enantiodivergent C(sp<sup>3</sup>)–H insertion: exploring the mechanism and origin of stereoselectivity-Reference-Cited by-同舟云学术

Role of mutations in a chemoenzymatic enantiodivergent C(sp³)–H insertion: exploring the mechanism and origin of stereoselectivity

Published:2023 Issue:33 Volume:14 Page:8810-8822
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Chatterjee Ritwika¹,Jindal Garima¹^ORCID

Affiliation:

1. Department of Organic Chemistry, Chemical Sciences Division, Indian Institute of Science, Bangalore, 560012, India

Abstract

A molecular level understanding into the role of mutations in a cytochrome P450 catalyzed enantiodivergent carbene insertion reaction is provided through the use of computational tools.

Funder

Ministry of Education, India

Board of Research in Nuclear Sciences

Department of Atomic Energy, Government of India

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC02788K

Reference73 articles.

1. Enantio- and Diastereodivergent Dual Catalysis

2. Stereodivergent Dual Catalytic α‐Allylation of Protected α‐Amino‐ and α‐Hydroxyacetaldehydes

3. Copper-catalysed enantioselective stereodivergent synthesis of amino alcohols

4. Enantiocomplementary Enzymes: Classification, Molecular Basis for Their Enantiopreference, and Prospects for Mirror-Image Biotransformations

5. Directed evolution drives the next generation of biocatalysts

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Heme‐Enzymatic Biocatalysis for C−C or C−N Bond Formation;ChemCatChem;2024-09-12

2. The Unique Role of the Second Coordination Sphere to Unlock and Control Catalysis in Nonheme Fe(II)/2-Oxoglutarate Histone Demethylase KDM2A;Inorganic Chemistry;2024-05-23