Label-free technology for the amplified detection of microRNA based on the allosteric hairpin DNA switch and hybridization chain reaction
Author:
Affiliation:
1. School of Pharmacy
2. Fudan University
3. Shanghai, China
Abstract
By using the allosteric hairpin DNA switch, a novel label-free assay for the detection of microRNA (miRNA) let-7a via a hybridization chain reaction (HCR) was introduced, which can achieve ultrasensitivity up to approximately 0.1 fmol, i.e. 1 pM.
Publisher
Royal Society of Chemistry (RSC)
Subject
Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2014/AN/C4AN01178C
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