Cancer cell membrane-camouflaged and H2O2-activatable nanocomposites for synergistic chemotherapy and two-photon photodynamic therapy against melanoma

Author:

Gao Siyuan1,Wei Fangmian1,Karges Johannes2ORCID,Zhao Yukun3,Ji Liangnian1,Chao Hui14ORCID

Affiliation:

1. MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510006, P. R. China

2. Faculty of Chemistry and Biochemistry, Ruhr-University Bochum, Universitätsstrasse 150, 44780 Bochum, Germany

3. Department of Dermatology, The Eastern Division of the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510275, P. R. China

4. MOE Key Laboratory of Theoretical Organic Chemistry and Functional Molecule, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, 400201, P. R. China

Abstract

An encapsulation of cyclometalated iridium(iii) prodrugs into selenium nanoparticles, which were further camouflaged with cancer cell membranes, was developed for synergistic chemotherapy and two-photon photodynamic therapy against melanoma.

Funder

National Natural Science Foundation of China

Science and Technology Program of Hunan Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

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