Synthesis of hydrazone-based polyhydroquinoline derivatives – antibacterial activities, α-glucosidase inhibitory capability, and DFT study-Reference-Cited by-同舟云学术

Synthesis of hydrazone-based polyhydroquinoline derivatives – antibacterial activities, α-glucosidase inhibitory capability, and DFT study

Published:2024 Issue:16 Volume:14 Page:10978-10994
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Ismail Muhammad¹²,Ahmad Rashid¹^ORCID,Halim Sobia Ahsan³,Khan Adnan Ali¹²^ORCID,Ullah Saeed³,Latif Abdul¹,Ahmad Manzoor¹,Khan Ajmal³,Ozdemir Fethi Ahmet⁴^ORCID,Khalid Asaad⁵,Al-Harrasi Ahmed³,Ali Mumtaz¹^ORCID

Affiliation:

1. Department of Chemistry, University of Malakand, P.O. Box 18800, Dir Lower, Khyber Pakhtunkhwa, Pakistan

2. Central for Computational Materials Science, P.O. Box 18800, Dir Lower, Khyber Pakhtunkhwa, Pakistan

3. Natural and Medical Sciences Research Center, University of Nizwa, Nizwa 616, Oman

4. Department of Molecular Biology and Genetics, Faculty of Science and Art, Bingol University, Bingol, Turkey

5. Substance Abuse and Toxicology Research Center, Jazan University, P.O. Box: 114, Jazan 45142, Saudi Arabia

Abstract

Hydrazone-based polyhydroquinoline derivatives are synthesized and characterized through modern spectroscopic techniques, compounds showed high potency and inhibitory activity. Molecular docking and DFT analyses were performed to predict structure activity relationship, electronic properties etc.

Funder

Ministry of Education – Kingdom of Saudi Arabi

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA00045E

Reference38 articles.

1. Recent developments in the nanomaterial-catalyzed green synthesis of structurally diverse 1,4-dihydropyridines

2. Enaminones in Heterocyclic Syntheses: Part 4. A New One-Step Synthetic Route to Pyrrolo[3,4-b]pyridine and Convenient Syntheses of 1,4-Dihydropyridines and 1,1′-(1,4-Phenylene)bis(1,4-dihydropyridine)

3. Magnetic guanidinylated chitosan nanobiocomposite: A green catalyst for the synthesis of 1,4-dihydropyridines

4. Construction and Aromatization of Hantzsch 1,4‐Dihydropyridines under Microwave Irradiation: A Green Approach

5. The status of isocyanide-based multi-component reactions in Iran (2010–2018)