Integration of transcriptomics and metabolomics to reveal the effect of ginsenoside Rg3 on allergic rhinitis in mice

Author:

Liu Jianming1,Yang Na2,Yi Xingcheng3,Wang Guoqiang4,Wang Cuizhu5,Lin Hongqiang4,Sun Liwei1,Wang Fang4,Zhu Dongdong16ORCID

Affiliation:

1. Department of Otolaryngology Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun 130021, China

2. Clinical Pharmacy Department, First Hospital of Jilin University, Changchun 130021, China

3. Laboratory of Cancer Precision Medicine, First Hospital of Jilin University, Changchun 130061, China

4. Department of Pathogen Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China

5. School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China

6. Jilin Provincial Key Laboratory of Precise Diagnosis and Treatment of Upper Airway Allergic Diseases, Changchun 130021, China

Abstract

Ginsenoside Rg3 has a protective effect against AR. The gene-metabolite network that played the main role in AR mice under Rg3 treatment has been explored by the integrated metabolomic and transcriptomic strategy.

Funder

Natural Science Foundation of Jilin Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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