Triphala inhibits alpha-synuclein fibrillization and their interaction study by NMR provides insights into the self-association of the protein
Author:
Affiliation:
1. Department of Chemical Sciences
2. Tata Institute of Fundamental Research
3. Mumbai 400005
4. India
5. UM-DAE Centre for Excellence in Basic Sciences
6. University of Mumbai
7. Kalina Campus
8. Mumbai 400098
9. Department of Biological Sciences
Abstract
Triphala inhibits αSyn self-association by interacting with anchoring regions which are responsible for αSyn oligomerization.
Funder
Tata Institute of Fundamental Research
Department of Atomic Energy, Government of India
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2019/RA/C9RA05551G
Reference77 articles.
1. NACP, A Protein Implicated in Alzheimer's Disease and Learning, Is Natively Unfolded
2. The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease
3. Fatal attractions: abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia
4. Alpha-synuclein in Lewy Body Disease and Alzheimer's Disease
5. α-Synuclein Locus Triplication Causes Parkinson's Disease
Cited by 7 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Amine Group Surface-Functionalized Carbon Quantum Dots Exhibit Anti-amyloidogenic Effects Towards Hen Egg White Lysozyme by Inducing Formation of Nontoxic Spherical Aggregates;The Protein Journal;2023-10-07
2. Targeting disorders in unstructured and structured proteins in various diseases;Biophysical Chemistry;2022-02
3. Pyrogallol, Corilagin and Chebulagic acid target the “fuzzy coat” of alpha-synuclein to inhibit the fibrillization of the protein;RSC Advances;2022
4. Cholesterol in Synaptic Vesicle Membranes Regulates the Vesicle-Binding, Function, and Aggregation of α-Synuclein;The Journal of Physical Chemistry B;2021-09-02
5. Conformational distortion in a fibril-forming oligomer arrests alpha-Synuclein fibrillation and minimizes its toxic effects;Communications Biology;2021-05-03
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3