The biorelevant concentration of Tween 80 solution is a simple alternative medium to simulated fasted state intestinal fluid-Reference-Cited by-全球学者库

The biorelevant concentration of Tween 80 solution is a simple alternative medium to simulated fasted state intestinal fluid

Published:2015 Issue:127 Volume:5 Page:104846-104853
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Yang Bin¹²³⁴,Wu Chunnuan⁵⁶⁴,Ji Bin⁷²³⁴,Ai Xiaoyu⁸⁹⁴,Kuang Xiao¹²³⁴,Wu Mingrui¹²³⁴,Sun Mengchi¹²³⁴,Luo Cong¹²³⁴,He Zhonggui¹²³⁴,Sun Jin¹²³⁴¹⁰

Affiliation:

1. Department of Pharmaceutics

2. School of Pharmacy

3. Shenyang Pharmaceutical University

4. China

5. Department of Pharmacy

6. Tianjin Medical University Cancer Institute and Hospital

7. Department of Pharmaceutical Analysis

8. College of Pharmacy

9. Nankai University

10. Municipal Key Laboratory of Biopharmaceutics

Abstract

The aim of the present study is to investigate whether the use of the biorelevant concentration of conventional surfactants as an alternative medium to simulated fasted state intestinal fluid for drugs with different acid–base properties is feasible.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA17674C

Reference24 articles.

1. Dissolution Testing for Poorly Soluble Drugs: A Continuing Perspective

2. Discriminatory dissolution method for quality control measurements of carbamazepine immediate release tablets based onin vitro–in vivoinvestigations

3. Considerations in the development of anin vitrodissolution condition for lacidipine tablets:in vivopharmacokinetic evaluation

4. Development of a dissolution medium for nimodipine tablets based on bioavailability evaluation

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