Mitochondria-targeted nanocarriers doubled the toxicity of oxidative phosphorylation and ATP synthesis disruptive insecticides against Spodoptera frugiperda

Author:

Hao Youwu1ORCID,Liu Di1,Song Yonghui1,Yin Xinming1,Liu Jia1ORCID,Na Risong1ORCID,Li Qing X.2ORCID

Affiliation:

1. National Key Laboratory of Wheat and Maize Crop Science, College of Plant Protection, Henan Agricultural University, 450002, Zhengzhou, China

2. Department of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, 1955 East-West Road, Honolulu, HI 96822, USA

Abstract

A mitochondria-targeted pesticide delivery system (MSN-CMC-TPP) for the ATP synthesis disruptor chlorfenapyr (Chl) was developed. The MSN-CMC-TPP system enhanced Chl efficacy by inducing mitochondrial damage in Sf9 cells.

Funder

U.S. Department of Agriculture

Earmarked Fund for China Agriculture Research System

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Environmental Science,Materials Science (miscellaneous)

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