Rivaroxaban eutectics with improved solubility, dissolution rates, bioavailability and stability-Reference-Cited by-同舟云学术

Rivaroxaban eutectics with improved solubility, dissolution rates, bioavailability and stability

Published:2023 Issue:22 Volume:25 Page:3253-3263
ISSN:1466-8033
Container-title:CrystEngComm
language:en
Short-container-title:CrystEngComm

Author:

Shaligram Parth S.¹²,George Christy P.¹³,Sharma Himanshu¹³,Mahadik Kakasaheb R.²,Patil Sharvil²,Vanka Kumar¹³^ORCID,Arulmozhi S.²,Gonnade Rajesh G.¹³^ORCID

Affiliation:

1. Physical and Materials Chemistry Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pashan, Pune, 411008 India

2. Poona College of Pharmacy, Bharati Vidyapeeth Deemed to be University, Erandwane, Pune-411038, Maharashtra, India

3. Academy of Scientific and Innovative Research (AcSIR), Sector 19, Kamla Nehru Nagar, Ghaziabad, Uttar Pradesh 201002, India

Abstract

Six acidic coformers were used to prepare eutectics of rivaroxaban (RXB), a factor Xa inhibitor. The eutectics displayed improved solubility, dissolution rate, and bioavailability of RXB, without compromising on its stability.

Funder

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CE/D3CE00261F

Reference44 articles.

1. Preclinical and clinical data for factor Xa and “universal” reversal agents

2. Rivaroxaban: An Oral Factor Xa Inhibitor

3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/022406s028lbl.pdf

4. Rivaroxaban for Thromboprophylaxis in High-Risk Ambulatory Patients with Cancer

5. The selectivity and bioavailability improvement of novel oral anticoagulants: An overview

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Eutectic Mixtures of APIs: A way to Improve the Physiochemical Properties and Oral Bioavailability of the Drugs;ChemistrySelect;2024-08-16

2. Elucidating of Fluconazole Cocrystallization With a Cutting-Edge Nutraceutical Coformer for Enhanced Formulation Strategies;Journal of Pharmaceutical Innovation;2024-06-25

3. The development of an innovative method to improve the dissolution performance of rivaroxaban;Heliyon;2024-06

4. A solid-state NMR method for characterization of pharmaceutical eutectics;Physical Chemistry Chemical Physics;2024