An isocratic RP-HPLC-UV method for simultaneous quantification of tizanidine and lidocaine: application to in vitro release studies of a subcutaneous implant

Author:

Picco Camila J.1,Anjani Qonita Kurnia1,Donnelly Ryan F.1ORCID,Larrañeta Eneko1ORCID

Affiliation:

1. School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK

Abstract

An isocratic RP-HPLC-UV method have been developed to evaluate simultaneously the release of tizanidine and lidocaine from subcutaneous implants.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

Reference80 articles.

1. Update on tizanidine for muscle spasticity and emerging indications

2. Validated liquid chromatography method for assay of tizanidine in drug substance and formulated products

3. N. L. of M. N. C. for B. I. PubChem , Tizanidine hydrochloride , https://pubchem.ncbi.nlm.nih.gov/compound/Tizanidine-hydrochloride#section=Computed-Properties , accessed 4 May 2023

4. Spasticity: pathophysiology, evaluation and management

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