Spermine amides of selected triterpenoid acids: dynamic supramolecular system formation influences the cytotoxicity of the drugs-Reference-Cited by-同舟云学术

Spermine amides of selected triterpenoid acids: dynamic supramolecular system formation influences the cytotoxicity of the drugs

Published:2020 Issue:3 Volume:8 Page:484-491
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Bildziukevich Uladzimir¹²³⁴⁵^ORCID,Malík Matěj¹²³⁴,Özdemir Zulal¹²³⁴⁵^ORCID,Rárová Lucie⁶⁷⁸⁹⁴^ORCID,Janovská Lucie⁶⁷⁸⁹⁴,Šlouf Miroslav¹⁰¹¹⁴^ORCID,Šaman David¹²¹³⁴,Šarek Jan¹⁴¹⁵⁴^ORCID,Nonappa Nonappa¹⁶¹⁷¹⁸¹⁹²⁰^ORCID,Wimmer Zdeněk¹²³⁴⁵^ORCID

Affiliation:

1. University of Chemistry and Technology in Prague

2. Department of Chemistry of Natural Compounds

3. 16628 Prague 6

4. Czech Republic

5. Institute of Experimental Botany of the Czech Academy of Sciences

6. Laboratory of Growth Regulators

7. Faculty of Science

8. Palacký University, and Institute of Experimental Botany of the Czech Academy of Sciences

9. 78371 Olomouc

10. Institute of Macromolecular Chemistry of the Czech Academy of Sciences

11. 16206 Prague 6

12. Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

13. Flemingovo náměstí 2

14. Jan Šarek, Betulinines

15. 28167 Stříbrná Skalice

16. Aalto University

17. School of Science

18. Department of Applied Physics

19. FI-00076 Espoo

20. Finland

Abstract

Cytotoxicity data: 8a: IC₅₀ [μM]: 18.8/31.8/32.6/17.2 (25.1 ± 8.2), due to the dynamic self-assembly found, low-contrast networks (TEM); 8b: IC₅₀ [μM]: 7.5 ± 1.6, dynamic self-assembly not detected, partly helical structures (TEM).

Funder

Ministerstvo Školství, Mládeže a Tělovýchovy

Ministerstvo Průmyslu a Obchodu

European Regional Development Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2020/TB/C9TB01957J

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