Structure and dynamics of γ-secretase with presenilin 2 compared to presenilin 1
Author:
Affiliation:
1. Department of Chemistry
2. Technical University of Denmark
3. DK-2800 Kongens Lyngby
4. Denmark
5. Department of Biochemistry
6. University of Cambridge
7. Cambridge
8. UK
Abstract
We constructed a model of presenilin-2 γ-secretase in the membrane and studied it by all-atom molecular dynamics simulations. The study provides the first structural-dynamic comparison of presenilin 1 and 2 relevant to Alzheimer's disease.
Funder
Novo Nordisk Fonden
Sundhed og Sygdom, Det Frie Forskningsråd
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2019/RA/C9RA02623A
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