Combined bortezomib-based chemotherapy and p53 gene therapy using hollow mesoporous silica nanospheres for p53 mutant non-small cell lung cancer treatment-Reference-Cited by-同舟云学术

Combined bortezomib-based chemotherapy and p53 gene therapy using hollow mesoporous silica nanospheres for p53 mutant non-small cell lung cancer treatment

Published:2017 Issue:1 Volume:5 Page:77-88
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Li Chun¹²³⁴⁵,Hu Junqing¹²³⁴⁵,Li Wenyao⁶⁷⁸⁴⁵,Song Guosheng¹²³⁴⁵,Shen Jia⁹¹⁰¹¹¹²⁵

Affiliation:

1. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials

2. College of Materials Science and Engineering

3. Donghua University

4. Shanghai 201620

5. China

6. School of Material Engineering

7. Research & Development Center for Key Technologies of Intelligent Ultra-Intense Laser Processing Equipments

8. Shanghai University of Engineering Science

9. State Key Laboratory of Molecular Biology; Institute of Biochemistry and Cell Biology

10. Shanghai Institutes for Biological Sciences

11. Chinese Academy of Sciences

12. Shanghai 200031

Abstract

Hollow mesoporous silica nanospheres (HMSN)-based co-delivery of bortezomib (BTZ) and the tumor suppressor gene p53 was developed for p53 signal impaired NSCLC therapy.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2017/BM/C6BM00449K

Reference34 articles.

1. Bortezomib as the First Proteasome Inhibitor Anticancer Drug: Current Status and Future Perspectives

2. Bortezomib and dexamethasone induction for multiple myeloma

3. Bortezomib for the Treatment of Mantle Cell Lymphoma

4. Bortezomib: a proteasome inhibitor with an evolving role in select subtypes of B-cell non-Hodgkin’s lymphoma

5. Bortezomib, but not cisplatin, induces mitochondria-dependent apoptosis accompanied by up-regulation of noxa in the non–small cell lung cancer cell line NCI-H460

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