Amyloid binding and beyond: a new approach for Alzheimer's disease drug discovery targeting Aβo–PrPC binding and downstream pathways-Reference-Cited by-同舟云学术

Amyloid binding and beyond: a new approach for Alzheimer's disease drug discovery targeting Aβo–PrPC binding and downstream pathways

Published:2021 Issue:10 Volume:12 Page:3768-3785
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Grayson James D.¹²³⁴,Baumgartner Matthew P.⁵⁶⁷⁸⁹,Santos Souza Cleide Dos¹²³⁴,Dawes Samuel J.¹²³⁴¹⁰,El Idrissi Imane Ghafir¹¹¹²¹³¹⁴,Louth Jennifer C.¹²³⁴,Stimpson Sasha¹²³⁴,Mead Emma¹⁵⁶¹⁶⁴,Dunbar Charlotte¹⁵⁶¹⁶⁴,Wolak Joanna¹⁵⁶¹⁶⁴,Sharman Gary¹⁵⁶¹⁶⁴,Evans David¹⁵⁶¹⁶⁴^ORCID,Zhuravleva Anastasia¹⁰¹⁷¹⁸⁴,Roldan Margarita Segovia¹⁹²²⁰⁴,Colabufo Nicola Antonio¹¹¹²¹³¹⁴¹¹^ORCID,Ning Ke¹⁹²²⁰⁴,Garwood Claire¹⁹²²⁰⁴,Thomas James A.¹²³⁴^ORCID,Partridge Benjamin M.¹²³⁴^ORCID,de la Vega de Leon Antonio²¹²²²⁴^ORCID,Gillet Valerie J.²¹²²²⁴,Rauter Amélia P.²³²⁴²⁵²⁶²⁷^ORCID,Chen Beining¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. University of Sheffield

3. Sheffield S3 7HF

4. UK

5. Computational Chemistry and Cheminformatics

6. Eli Lilly and Company

7. Lilly Biotechnology Center

8. San Diego

9. USA

10. Faculty of Biological Sciences

11. Univ Bari

12. Biofordrug

13. I-70125 Bari

14. Italy

15. Computational Chemistry and Chemoinformatics

16. Windlesham

17. University of Leeds

18. Leeds LS2 9JT

19. Sheffield Institute of Translational Neuroscience

20. Sheffield S10 2HQ

21. Information School

22. Sheffield S1 4DP

23. Centro de Química Estrutural

24. Faculdade de Ciências

25. Universidade de Lisboa

26. 1749-016 Lisboa

27. Portugal

Abstract

A new approach combining virtual screening, ¹⁹F and STD NMR, and biochemical assays using hiPSC and targetting multiple pathways involving Aβ, PrP^C and Tau provides a more effective strategy for Alzheimer's disease drug discovery than Aβ only approach.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D0SC04769D

Reference73 articles.

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2. The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: Implications for Alzheimer's disease

3. Alzheimer's Disease: The Amyloid Cascade Hypothesis

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5. The amyloid hypothesis of Alzheimer's disease at 25 years

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