Metronidazole-modified Au@BSA nanocomposites for dual sensitization of radiotherapy in solid tumors

Author:

Du Qijun12,Yuen Ho-Yin3,Pan Jingke12,Sun Chenwei12,Wu Di12,Liu Jie12,Wu Guohua4,Zhao Xin3ORCID,Wang Shuqi1256ORCID

Affiliation:

1. College of Biomedical Engineering, Sichuan University, Chengdu 610065, China

2. National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610065, China

3. Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong 999077, China

4. Luoyang Key Laboratory of Clinical Multiomics and Translational Medicine, Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, China

5. Tianfu Jincheng Laboratory, City of Future Medicine, Chengdu 641400, China

6. Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu 610065, China

Abstract

A dual-sensitizing ABMN nanocomposite was designed and developed to improve the sensitivity of radiotherapy to tumor cells and promote the efficacy of tumor cell killing by exploiting the tumor microenvironment's oxygen deficiency.

Funder

National Key Scientific Instrument and Equipment Development Projects of China

National Key Research and Development Program of China

West China Hospital, Sichuan University

Research Grants Council, University Grants Committee

Applied Basic Research Program of Sichuan Province

Publisher

Royal Society of Chemistry (RSC)

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