Trichloranoids A–D, antimalarial sesquiterpenoid trimers from Chloranthus spicatus

Author:

Zhou Jun-Su12345ORCID,Liu Qun-Fang12345,Zimbres Flavia M.6789,Butler Joshua H.6789,Cassera Maria B.6789,Zhou Bin12345ORCID,Yue Jian-Min12345ORCID

Affiliation:

1. State Key Laboratory of Drug Research

2. Shanghai Institute of Materia Medica

3. Chinese Academy of Sciences

4. Shanghai 201203

5. People's Republic of China

6. Department of Biochemistry and Molecular Biology and Center for Tropical and Emerging Global Diseases (CTEGD)

7. University of Georgia

8. Athens

9. USA

Abstract

Four new anti-malarial sesquiterpenoid trimers including two rearranged skeletons were isolated from Chloranthus spicatus. The structurally different but biogenetically related compounds 1, 2 and 5 rationalized the biradical pathway, and vice versa.

Funder

National Natural Science Foundation of China

Chinese Academy of Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

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