Translesion DNA synthesis across double-base lesions derived from cross-links of an antitumor trinuclear platinum compound: primer extension, conformational and thermodynamic studies-Reference-Cited by-同舟云学术

Translesion DNA synthesis across double-base lesions derived from cross-links of an antitumor trinuclear platinum compound: primer extension, conformational and thermodynamic studies

Published:2018 Issue:1 Volume:10 Page:132-144
ISSN:1756-5901
Container-title:Metallomics
language:en
Short-container-title:Metallomics

Author:

Novakova O.¹²³⁴⁵,Farrell N. P.⁶⁷⁸⁹^ORCID,Brabec V.¹²³⁴⁵^ORCID

Affiliation:

1. Institute of Biophysics

2. Czech Academy of Sciences

3. Kralovopolska 135

4. CZ-61265 Brno

5. Czech Republic

6. Department of Chemistry

7. Virginia Commonwealth University

8. Richmond

9. USA

Abstract

The central linker of antitumor polynuclear Triplatin represents an important factor responsible for the lowered tolerance of its DNA double-base adducts by DNA polymerases.

Funder

Grantová Agentura České Republiky

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2018/MT/C7MT00266A

Reference61 articles.

1. V. Brabec , J.Kasparkova , V.Menon and N. P.Farrell , in Metal Ions in Life Sciences , ed. A. Sigel , H. Sigel , E. Freisinger and R. K. O. Sigel , Walter de Gruyter, GmbH , Berlin, Germany , 2018 , vol. 18, Metallo-Drugs: Development and Action of Anticancer Agents, pp. 43–68

2. DNA Modifications by a Novel Bifunctional Trinuclear Platinum Phase I Anticancer Agent

3. A comparison of DNA binding profiles of dinuclear platinum compounds with polyamine linkers and the trinuclear platinum phase II clinical agent BBR3464

4. Competitive formation of DNA linkage isomers by a trinuclear platinum complex and the influence of pre-association

5. The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

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