Exploring the conformational dynamics of the SARS-CoV-2 SL4 hairpin by combining optical tweezers and base analogues

Author:

Sundar Rajan Vinoth12ORCID,Wypijewska del Nogal Anna2ORCID,Levin Sune1,Wilhelmsson L. Marcus2ORCID,Westerlund Fredrik1ORCID

Affiliation:

1. Division of Chemical Biology, Department of Life Sciences, Chalmers University of Technology, Gothenburg, SE-412 96, Sweden

2. Division of Chemistry and Biochemistry, Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Gothenburg, SE-412 96, Sweden

Abstract

We characterize the stability, conformational dynamics, (un)folding pathways, as well as identify a promising drug–target site within the SL4 hairpin of the SARS-CoV-2 by combining base analogues and optical tweezers.

Funder

Chalmers Tekniska Högskola

H2020 European Research Council

Stiftelsen för Strategisk Forskning

Vetenskapsrådet

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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