A lipid–polymer hybrid nanoparticle (LPN)-loaded dissolving microneedle patch for promoting hair regrowth by transdermal miR-218 delivery-Reference-Cited by-同舟云学术

A lipid–polymer hybrid nanoparticle (LPN)-loaded dissolving microneedle patch for promoting hair regrowth by transdermal miR-218 delivery

Published:2023 Issue:1 Volume:11 Page:140-152
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Zhao Yipu¹²³,Tian Ye¹²³^ORCID,Ye Weiliang⁴^ORCID,Wang Xue¹²³,Huai Ying¹²³,Huang Qian¹²³,Chu Xiaohua¹²³,Deng Xudong¹²³^ORCID,Qian Airong¹²³^ORCID

Affiliation:

1. Lab for Bone Metabolism, Xi'an Key Laboratory of Special Medicine and Health Engineering; Key Lab for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi, China

2. Research Center for Special Medicine and Health Systems Engineering, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi, China

3. NPU-UAB Joint Laboratory for Bone Metabolism, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi, 710072, China

4. Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an, China

Abstract

A miRNA transdermal delivery device for alopecia therapy that combines the use of hyaluronic acid (HA)-based dissolving MN to enhance corneum permeability with lipid polymer hybrid nanoparticles (LPNs) to protect miR-218 from degradation.

Funder

Key Research and Development Projects of Shaanxi Province

Fundamental Research Funds for the Central Universities

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2023/BM/D2BM01454H

Reference50 articles.

1. The Alopecia Areata Consensus of Experts (ACE) study part II: Results of an international expert opinion on diagnosis and laboratory evaluation for alopecia areata