Design and evaluation of nanoscale materials with programmed responsivity towards epigenetic enzymes-Reference-Cited by-同舟云学术

Design and evaluation of nanoscale materials with programmed responsivity towards epigenetic enzymes

Published:2024 Issue: Volume: Page:
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Ray Priyanka¹^ORCID,Sedigh Abbas²,Confeld Matthew³,Alhalhooly Lina⁴,Iduoku Kweeni¹,Casanola-Martin Gerardo M.¹^ORCID,Pham-The Hai⁵^ORCID,Rasulev Bakhtiyor¹^ORCID,Choi Yongki⁴^ORCID,Yang Zhongyu²^ORCID,Mallik Sanku²^ORCID,Quadir Mohiuddin¹^ORCID

Affiliation:

1. Department of Coatings and Polymeric Materials, North Dakota State University, Fargo, ND 58102, USA

2. Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND 58102, USA

3. Deapartment of Physics, North Dakota State University, Fargo, ND 58102, USA

4. Department of Chemistry and Biochemistry, North Dakota State University, Fargo, ND 58102, USA

5. University of Science and Technology of Hanoi, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 10000, Vietnam

Abstract

This study presents the synthesis of enzyme-responsive nanoparticles targeting HDAC8, an epigenetic enzyme, through a deacetylation reaction. This first-time report highlights the potential for these particles to mimic synthetic histones.

Funder

National Institute of General Medical Sciences

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/TB/D4TB00514G

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4. Enzyme-Triggered Cargo Release from Methionine Sulfoxide Containing Copolypeptide Vesicles

5. Propagation of Enzyme‐Induced Surface Events inside Polymer Nanoassemblies for a Fast and Tunable Response