A cell membrane-targeting AIE photosensitizer as a necroptosis inducer for boosting cancer theranostics

Author:

Niu Niu12ORCID,Yu Ying3,Zhang Zhijun12,Kang Miaomiao12ORCID,Wang Lei12ORCID,Zhao Zheng3,Wang Dong12ORCID,Tang Ben Zhong3ORCID

Affiliation:

1. Center for AIE Research, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Material Science and Engineering, Shenzhen University, Shenzhen 518060, China

2. College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China

3. School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172, China

Abstract

A membrane-targeting photosensitizer TBMPEI with AIE properties was synthesized via a new acceptor, and it was utilized as a necroptosis inducer during imaging-guided photodynamic therapy.

Funder

National Natural Science Foundation of China

Science and Technology Foundation of Shenzhen City

Natural Science Foundation of Guangdong Province for Distinguished Young Scholars

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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