Electrophilic amidomethylation of arenes with DMSO/MeCN reagents

Author:

Zhang Hongliang1,Wang Weijin1,Wang Bingding1,Tan Hui1,Jiao Ning1ORCID,Song Song12ORCID

Affiliation:

1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road 38, Beijing 100191, China

2. State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Jiangsu 210023, China

Abstract

An efficient electrophilic amidomethylation of aromatics was described with DMSO as the CH2 source and nitrile as the nitrogen source.

Funder

National Key Research and Development of China

Beijing Nova Program

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

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