Impact of linker between triazolyluracil and phenanthridine on recognition of DNA and RNA. Recognition of uracil-containing RNA

Author:

Saftić Dijana12345,Radić Stojković Marijana12345,Žinić Biserka12345,Glavaš-Obrovac Ljubica6789ORCID,Jukić Marijana6789ORCID,Piantanida Ivo12345,Tumir Lidija-Marija12345ORCID

Affiliation:

1. Laboratory for Biomolecular Interactions and Spectroscopy

2. Division of Organic Chemistry & Biochemistry

3. Ruđer Bošković Institute

4. P.O.B. 180

5. HR 10002 Zagreb

6. Department of Medicinal Chemistry and Biochemistry

7. School of Medicine Osijek

8. 31000 Osijek

9. Croatia

Abstract

A phenanthridine-triazolyluracilyl multifunctional ligand, linked by a lysine–glycine peptide, binds to poly rA–poly rU with micromolar affinity and selective fluorescence response.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Reference75 articles.

1. M. Chastain and I.Tinoco Jr., in Progress in Nucleic Acid Research and Molecular Biology, ed. W. E. Cohn, K. Moldave, Academic NY, 1991, vol. 41, pp. 131–177

2. W. Saenger , Principles of Nucleic Acid Structure, Springer, New York, 1988

3. Effects of Minor Groove Binding Drugs on the Interaction of TATA Box Binding Protein and TFIIA with DNA

4. R. B. Silverman , The Organic Chemistry of Drug Design and Drug Action, Elsevier Academic Press, 2nd edn, 2004

5. DNA and RNA Binders, ed. M. Demeunynck, C. Bailly and W. D. Wilson, Wiley-VCH, Weinheim, Germany, 2002

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