Nuclear delivery of dual anti-cancer drugs by molecular self-assembly

Author:

Wu Jindao12345ORCID,Ding Wenzhou12345,Han Guoyong12345,You Wei12345,Gao Wen12345,Shen Hongbing678910,Tang Jinhai12345,Tang Qiyun12345,Wang Xuehao12345

Affiliation:

1. Key Laboratory of Liver Transplantation

2. Chinese Academy of Medical Sciences

3. Hepatobiliary Center

4. Department of Breast Surgery

5. Department of Oncology

6. Department of Epidemiology and Biostatistics

7. State Key Laboratory of reproductive medicine

8. NHC Key Laboratory of Living Donor Liver Transplantation

9. Jiangsu Key Lab of Cancer Biomarkers

10. Prevention and Treatment

Abstract

Nanomedicines generally suffer from poor accumulation in tumor cells, low anti-tumor efficacy, and drug resistance. In order to address these problems, we introduced a novel nanomedicine based on dual anti-cancer drugs, which showed good cell nuclear accumulation properties.

Funder

National Natural Science Foundation of China

Jiangsu University

Nanjing Medical University

Jiangsu Provincial Medical Youth Talent

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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