Emergency diagnosis made easy: matrix removal and analyte enrichment from raw saliva using paper-arrow mass spectrometry

Author:

Zhou Yufeng1,Sham Tung-Ting1ORCID,Boisdon Cedric1,Smith Barry L.1,Blair Joanne C.2,Hawcutt Daniel B.34,Maher Simon1ORCID

Affiliation:

1. Department of Electrical Engineering and Electronics, University of Liverpool, Brownlow Hill, Liverpool, UK

2. Department of Endocrinology, Alder Hey Children's Hospital, Liverpool, UK

3. NIHR Clinical Research Facility, Alder Hey Children's Hospital, Liverpool, UK

4. Department of Women's and Children's Health, University of Liverpool, UK

Abstract

Paper Arrow combines sample collection, extraction, separation, pre-concentration and ionisation onto a single paper strip enabling rapid, accurate, cost-effective and eco-friendly analysis (herein: drug detection from 2 μL of raw saliva in <10 min).

Funder

Alder Hey Children's NHS Foundation Trust

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

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