Copper affects the binding of HIF-1α to the critical motifs of its target genes
Author:
Affiliation:
1. Regenerative Medicine Research Center
2. Sichuan University West China Hospital
3. Chengdu
4. China
5. Memphis Institute of Regenerative Medicine
Abstract
Copper regulates the target gene selection of HIF-1α under hypoxic conditions by affecting HIF-1α-DNA binding patterns across the genome.
Funder
National Natural Science Foundation of China
Publisher
Oxford University Press (OUP)
Subject
Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)
Link
http://pubs.rsc.org/en/content/articlepdf/2019/MT/C8MT00280K
Reference55 articles.
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4. Regulation of hypoxia-inducible factor 1 is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway
5. Hypoxia-Inducible Factor-1 (HIF-1)
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