The F19W mutation reduces the binding affinity of the transmembrane Aβ11–40 trimer to the membrane bilayer

Author:

Tran Thanh Thuy12345ORCID,Pan Feng6789,Tran Linh10113412,Roland Christopher1314159,Sagui Celeste1314159

Affiliation:

1. Laboratory of Theoretical and Computational Biophysics

2. Ton Duc Thang University

3. Ho Chi Minh City

4. Vietnam

5. Faculty of Applied Sciences

6. Department of Statistics

7. Florida State University

8. Tallahassee

9. USA

10. Institute of Fundamental and Applied Sciences

11. Duy Tan University

12. Faculty of Natural Sciences

13. Department of Physics

14. North Carolina State University

15. Raleigh

Abstract

Dominant conformations of F19W 3Aβ11–40 immersed in transmembrane DPPC lipid bilayer submerged in aqueous solution.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference89 articles.

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2. Beyond pathology: APP, brain development and Alzheimer's disease

3. The behavioural/dysexecutive variant of Alzheimer’s disease: clinical, neuroimaging and pathological features

4. Amyloid β Protein and Alzheimer’s Disease: When Computer Simulations Complement Experimental Studies

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