Sodium hypophosphite mediated reductive amination of carbonyl compounds with <i>N</i>,<i>N</i>-dialkylformamides-Reference-Cited by-同舟云学术

Sodium hypophosphite mediated reductive amination of carbonyl compounds with N,N-dialkylformamides

Published:2023 Issue:14 Volume:47 Page:6532-6535
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Fatkulin Artemy R.¹²^ORCID,Korochantsev Vasily¹²³,Afanasyev Oleg I.¹⁴^ORCID,Podyacheva Evgeniya¹²,Chusova Olga¹⁵,Muratov Dmitry V.¹,Godovikova Maria I.¹,Semenov Sergei³,Chusov Denis¹²^ORCID

Affiliation:

1. A.N.Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, INEOS, Vavilova St. 28, bld. 1, Moscow, 119334, Russia

2. National Research University Higher School of Economics, Miasnitskaya Str. 20, Moscow 101000, Russian Federation

3. Moscow South-Eastern School named after V.I. Chuikov (Moscow Chemical Lyceum), 4 Tamozhenniy proezd, 111033 Moscow, Russian Federation

4. Plekhanov Russian University of Economics, Stremyanny per. 36, 117997 Moscow, Russian Federation

5. Faculty of Science, RUDN University, 6 Miklukho-Maklaya St., Moscow, 117198, Russia

Abstract

Herein we report a transition-metal- and acid-free protocol for the reductive amination of carbonyl compounds with DMF using a substoichiometric amount of NaH2PO2·H2O. The general trends and limitations of the method were explored.

Funder

Russian Science Foundation

Ministry of Science and Higher Education of the Russian Federation

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NJ/D3NJ00728F

Reference37 articles.

1. Reductive Amination in the Synthesis of Pharmaceuticals

2. One-pot synthesis of pharmacologically active diamines via rhodium-catalysed carbonylative hydroaminomethylation of heterocyclic allylic amines

3. An alternative synthesis of the non-small cell lung carcinoma drug afatinib

4. Construction of dibenzo-fused seven- to nine-membered carbocycles via Brønsted acid-promoted intramolecular Friedel–Crafts-type alkenylation

5. Synthesis and characterization of antibacterial dental monomers and composites