Glutathione boosting the cytotoxicity of a magnetic platinum(iv) nano-prodrug in tumor cells-Reference-Cited by-全球学者库

Glutathione boosting the cytotoxicity of a magnetic platinum(iv) nano-prodrug in tumor cells

Published:2016 Issue:4 Volume:7 Page:2864-2869
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Zhu Zhenzhu¹²³⁴⁵,Wang Zenghui¹²³⁴⁵,Hao Yigang¹²³⁴⁵,Zhu Chengcheng¹²³⁴⁵,Jiao Yang¹²³⁴⁵,Chen Huachao¹²³⁴⁵,Wang Yun-Ming⁶⁷⁸⁹¹⁰,Yan Jun¹¹¹²¹³¹⁴⁵,Guo Zijian¹²³⁴⁵,Wang Xiaoyong¹¹¹⁵¹⁶³⁴

Affiliation:

1. State Key Laboratory of Coordination Chemistry

2. School of Chemistry and Chemical Engineering

3. Nanjing University

4. Nanjing 210023

5. P. R. China

6. Department of Biological Science and Technology

7. Institute of Molecular Medicine and Bioengineering

8. National Chiao Tung University

9. Hsinchu 300

10. Taiwan

11. State Key Laboratory of Pharmaceutical Biotechnology

12. MOE Key Laboratory of Model Animals for Disease Study

13. Model Animal Research Center of Nanjing University

14. Nanjing 210061

15. School of Life Sciences

16. State Key Laboratory of Analytical Chemistry for Life Science

Abstract

Fe₃O₄ nanoparticles with Pt-prodrug payloads display MRI capability and tumor-specific cytotoxicity correlating positively with glutathione-mediated DNA cleavage and reduction.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/SC/C5SC04049C

Reference28 articles.

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2. Cisplatin-induced nephrotoxicity and targets of nephroprotection: an update

3. Cisplatin resistance: Preclinical findings and clinical implications

4. Drug transporters of platinum-based anticancer agents and their clinical significance

5. Targeting and delivery of platinum-based anticancer drugs

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