Common precursor strategy for the synthesis of bestatin, amprenavir intermediate and syn-4-hydroxy-5-phenyl-γ-lactam
Author:
Affiliation:
1. Bio-organic Chemistry Division
2. Indian Institute of Integrative Medicine (CSIR)
3. Jammu, India-180001
4. Natural Product Microbe
Abstract
A synthetic strategy using α,β-unsaturated ester as a common precursor for the preparation of bestatin hydrochloride, an anticancer agent; 1,3-diaminoalcohol, an amprenavir intermediate and syn-4-hydroxy-5-phenyl-γ-lactam, an intermediate of bioactive molecules with good yields and excellent stereoselectivity is described.
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2014/RA/C4RA00205A
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