Rapid synthesis of hexahydropyrrolo[3,4-b]pyrrole-fused quinolines via a consecutive [3 + 2] cycloaddition and reduction/intramolecular lactamization cascade-Reference-Cited by-同舟云学术

Rapid synthesis of hexahydropyrrolo[3,4-b]pyrrole-fused quinolines via a consecutive [3 + 2] cycloaddition and reduction/intramolecular lactamization cascade

Published:2020 Issue:19 Volume:7 Page:2991-2996
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Lin Yan-Liang¹²³⁴⁵,Lee Yun-Ta¹²³⁴⁵,Barve Indrajeet J.¹²³⁴⁵,Huang Yi-Ting¹²³⁴⁵,Sun Chung-Ming¹²³⁴⁵^ORCID

Affiliation:

1. Department of Applied Chemistry

2. National Chiao-Tung University

3. 1001 Ta-Hsueh Road

4. Hsinchu 300-10

5. Republic of China

Abstract

An unprecedented synthesis of novel hexahydropyrrolo[3,4-b]pyrrole-fused quinolines is achieved through the sequential [3 + 2] cycloaddition reaction of azomethine ylides with maleimides followed by intramolecular lactamization.

Funder

Ministry of Science and Technology, Taiwan

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/QO/D0QO00858C

Reference23 articles.

1. Quantifying structure and performance diversity for sets of small molecules comprising small-molecule screening collections

2. Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

3. Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles

4. Two‐ and Three‐dimensional Rings in Drugs

5. Synthesis and evaluation of novel quinolinones as HIV-1 reverse transcriptase inhibitors

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