Plasma fibrin membranes loaded with bone marrow mesenchymal stem cells and corneal epithelial cells promote corneal injury healing via attenuating inflammation and fibrosis after corneal burns

Author:

Song Liqun1ORCID,Yang Xue1,Cui Huifei123ORCID

Affiliation:

1. Key Laboratory of Chemical Biology, Ministry of Education, Institute of Biochemical and Biotechnological Drugs, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China

2. National Glycoengineering Research Center, Cheeloo College of Medicine, Shandon University, Jinan, 250012, Shandong, China

3. Shandong Provincial Key Laboratory of Carbohydrate Chemistry end Glycobiology, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China

Abstract

A tissue-engineered corneal membrane for corneal injury was prepared. It can inhibit inflammation, promote differentiation of BMSCs into corneal epithelial cells, prevent corneal fibrosis and scar formation.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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