Deglycase-activity oriented screening to identify DJ-1 inhibitors-Reference-Cited by-同舟云学术

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Deglycase-activity oriented screening to identify DJ-1 inhibitors

Published:2021 Issue:7 Volume:12 Page:1232-1238
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Maksimovic Igor¹²³⁴⁵^ORCID,Finkin-Groner Efrat⁶²³^ORCID,Fukase Yoshiyuki⁶²³^ORCID,Zheng Qingfei⁴⁵²³^ORCID,Sun Shan⁶²³^ORCID,Michino Mayako⁶²³^ORCID,Huggins David J.⁶²³⁷⁸^ORCID,Myers Robert W.⁶²³^ORCID,David Yael¹²³⁴⁵^ORCID

Affiliation:

1. Tri-Institutional PhD Program in Chemical Biology

2. New York

3. USA

4. Chemical Biology Program

5. Memorial Sloan Kettering Cancer Center

6. Tri-Institutional Therapeutics Discovery Institute

7. Department of Physiology, Biophysics and Systems Biology

8. Weill Cornell Medicine

Abstract

Tracking the esterase activity of DJ-1 via a fluorescent-based scalable assay to uncover and develop candidates with enhanced potency.

Funder

National Institutes of Health

Parker Institute for Cancer Immunotherapy

Pershing Square Foundation

Takeda Pharmaceutical Company

Memorial Sloan-Kettering Cancer Center

Rockefeller University

Weill Cornell Medical College

Robertson Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D1MD00062D

Reference32 articles.

1. Translating the Histone Code

2. Regulation of chromatin by histone modifications

3. Non-enzymatic covalent modifications: a new link between metabolism and epigenetics

4. Nonenzymatic glycation of histones in vitro and in vivo

5. Non-enzymatic Covalent Modifications as a New Chapter in the Histone Code

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1. The origin of esterase activity of Parkinson's disease causative factor DJ-1 implied by evolutionary trace analysis of its prokaryotic homolog HchA;Journal of Biological Chemistry;2024-07

2. Development of Inhibitors, Probes, and PROTAC Provides a Complete Toolbox to Study PARK7 in the Living Cell;Journal of Medicinal Chemistry;2024-05-07

3. Epigenetic meets metabolism: novel vulnerabilities to fight cancer;Cell Communication and Signaling;2023-09-21

4. Computational Study of Base-Catalyzed Thiohemiacetal Decomposition in Pseudomonas mevalonii HMG-CoA Reductase;The Journal of Physical Chemistry B;2023-05-23

5. Leveraging histone glycation for cancer diagnostics and therapeutics;Trends in Cancer;2023-05

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