Chemical constituents from <i>Morus alba</i> with proprotein convertase subtilisin/kexin type 9 expression and secretion inhibitory activity-Reference-Cited by-同舟云学术

Chemical constituents from Morus alba with proprotein convertase subtilisin/kexin type 9 expression and secretion inhibitory activity

Published:2023 Issue:13 Volume:21 Page:2801-2808
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Won Hongic¹,Son Min-Gyung¹^ORCID,Pel Pisey¹,Nhoek Piseth¹,An Chae-Yeong¹^ORCID,Kim Young-Mi¹,Chae Hee-Sung¹,Chin Young-Won¹^ORCID

Affiliation:

1. College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea

Abstract

Twenty compounds were isolated from Morus alba using a PCSK9 expression monitoring assay. For the first time, it is found that betulinic acid may inherit a new role as a PCSK9 inhibitor.

Funder

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB00225J

Reference49 articles.

1. Platycodin D enhances LDLR expression and LDL uptake via down-regulation of IDOL mRNA in hepatic cells

2. Dyslipidemia Part 1—Review of Lipid Metabolism and Vascular Cell Physiology

3. Trend analysis of cardiovascular disease mortality, incidence, and mortality-to-incidence ratio: results from global burden of disease study 2017

4. Understanding hyperlipidemia and atherosclerosis: lessons from genetically modified apoe and ldlr mice

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Natural Products and Biological Activities of Plants from Genus Morus: 2011-2023;Current Topics in Medicinal Chemistry;2023-11

2. Acyclic Triterpenoids from Alpinia katsumadai Seeds with Proprotein Convertase Subtilisin/Kexin Type 9 Expression and Secretion Inhibitory Activity;ACS Omega;2023-08-25