Synthesis, molecular modeling and biological evaluation of aza-flavanones as α-glucosidase inhibitors-Reference-Cited by-同舟云学术

Synthesis, molecular modeling and biological evaluation of aza-flavanones as α-glucosidase inhibitors

Published:2017 Issue:8 Volume:8 Page:1618-1630
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Kasturi Sivaprasad¹²³⁴⁵^ORCID,Surarapu Sujatha¹²³⁴,Bathoju Chandra Chary¹²³⁴,Uppalanchi Srinivas¹²³⁴,Dwivedi Shubham⁶⁷⁸⁹¹⁰,Perumal Yogeeswari⁶⁷⁸⁹¹⁰,Sigalapalli Dilep Kumar¹¹¹¹²¹³,Babu Bathini Nagendra¹¹¹¹²¹³,Ethiraj Krishna S.¹²³⁴,Anireddy Jaya Shree⁵¹⁴¹⁵⁴^ORCID

Affiliation:

1. Department of Medicinal Chemistry

2. GVK Biosciences Pvt. Ltd

3. Hyderabad 500076

4. India

5. Centre for Chemical Sciences & Technology

6. Biology Division

7. Drug Discovery Research Laboratory

8. Department of Pharmacy

9. Birla Institute of Technology & Science-Pilani

10. Hyderabad 500078

11. National Institute of Pharmaceutical Education and Research (NIPER)

12. Hyderabad

13. 500037 India

14. Institute of Science and Technology

15. Hyderabad 500085

Abstract

An efficient acid catalyzed methodology has been employed to synthesize a variety of aza-flavanones and their α-glucosidase inhibitory activity is evaluated using acarbose, miglitol and voglibose as reference standards.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MD/C7MD00162B

Reference20 articles.

1. Sulfonamide chalcone as a new class of α-glucosidase inhibitors

2. Aromatic Nucleophilic Substitution or CuI-Catalyzed Coupling Route to Martinellic Acid

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