Disruption of mitochondrial redox homeostasis by enzymatic activation of a trialkylphosphine probe-Reference-Cited by-同舟云学术

Disruption of mitochondrial redox homeostasis by enzymatic activation of a trialkylphosphine probe

Published:2021 Issue:12 Volume:19 Page:2681-2687
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Nguyen Jade¹²³⁴⁵,Tirla Alina¹²³⁴,Rivera-Fuentes Pablo¹²³⁴⁵^ORCID

Affiliation:

1. Laboratory of Organic Chemistry

2. ETH Zurich

3. 8093 Zurich

4. Switzerland

5. Institute of Chemical Sciences and Engineering

Abstract

The release of tributylphosphine in mitochondria induces morphological changes and upregulates specific genes from the integrated stress response, such as CHAC1.

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D0OB02259D

Reference30 articles.

1. [11] Redox potential of GSH/GSSG couple: Assay and biological significance

2. Redox Imbalance and Biochemical Changes in Cancer

3. Redox Imbalance in Diabetes

4. Oxidative stress in Alzheimer’s disease

5. Redox compartmentalization and cellular stress

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